PHYTOCHEMICAL PROFILE AND GASTROPROTECTIVE ACTIVITY OF EUGENIA MATTOSII FRUITS.

BACKGROUND: Extracts obtained from plants and fruits provide a relatively safe and practical alternative for the conventional medicine of gastrointestinal diseases. The specie Eugenia mattosii, popularly known in Brazil as "cerejinha", belongs to Myrtaceae family. Species of this family present pharmacological properties, and can be used in the treatment of gastrointestinal disorders. OBJECTIVE: The aim of this study was to determine the phytochemical profile and evaluate the gastroprotective activity of Eugenia mattosii fruits. METHODS: Phytochemical analysis was carried out by thin layer chromatography and gastroprotective assays were performed using two experimental models: acute ulcer model induced by ethanol/HCl and acute ulcer model induced by non-steroidal anti-inflammatory drug (indomethacin). Total lesion area (mm2) and relative lesion area (%) were determined. RESULTS: The results of the phytochemical analysis indicated that the bark and pulp and seeds of E. mattosii present phenolic compounds, terpenes and/or steroids. In gastric ulcer model induced by ethanol was evidenced significant reduction of damaged areas for doses of 50 and 250 mg/ kg of seeds methanol extract, while in the indomethacin-induced ulcer model, all parts of the fruit presented defense capability of the gastric mucosa by reducing lesions at doses of 50, 125 and 250 mg/kg. CONCLUSION: The results demonstrate that the specie E. mattosii has bioactive compounds that provide gastroprotective activity, presenting possible therapeutic potential.

Perfil fitoquímico e atividade gastroprotetora dos frutos de Eugenia mattosii / Phytochemical profile and gastroprotective activity of eugenia mattosii fruits

ABSTRACT BACKGROUND: Extracts obtained from plants and fruits provide a relatively safe and practical alternative for the conventional medicine of gastrointestinal diseases. The specie Eugenia mattosii, popularly known in Brazil as "cerejinha", belongs to Myrtaceae family. Species of this family present pharmacological properties, and can be used in the treatment of gastrointestinal disorders. OBJECTIVE: The aim of this study was to determine the phytochemical profile and evaluate the gastroprotective activity of Eugenia mattosii fruits. METHODS: Phytochemical analysis was carried out by thin layer chromatography and gastroprotective assays were performed using two experimental models: acute ulcer model induced by ethanol/HCl and acute ulcer model induced by non-steroidal anti-inflammatory drug (indomethacin). Total lesion area (mm2) and relative lesion area (%) were determined. RESULTS: The results of the phytochemical analysis indicated that the bark and pulp and seeds of E. mattosii present phenolic compounds, terpenes and/or steroids. In gastric ulcer model induced by ethanol was evidenced significant reduction of damaged areas for doses of 50 and 250 mg/ kg of seeds methanol extract, while in the indomethacin-induced ulcer model, all parts of the fruit presented defense capability of the gastric mucosa by reducing lesions at doses of 50, 125 and 250 mg/kg. CONCLUSION: The results demonstrate that the specie E. mattosii has bioactive compounds that provide gastroprotective activity, presenting possible therapeutic potential.

RESUMO CONTEXTO: Extratos obtidos de plantas e frutos fornecem uma alternativa relativamente segura e prática para os remédios convencionais de doenças gastrointestinais. A espécie Eugenia mattosii, popularmente conhecida no Brasil como "cerejinha", pertence à família Myrtaceae. Espécies desta família apresentam propriedades farmacológicas e podem ser utilizadas no tratamento de distúrbios gastrointestinais. OBJETIVO: O objetivo deste estudo foi determinar o perfil fitoquímico e avaliar a atividade gastroprotetora dos frutos de Eugenia mattosii. MÉTODOS: A análise fitoquímica foi realizada por cromatografia em camada delgada e dois modelos experimentais foram utilizados para avaliação da atividade gastroprotetora em camundongos: modelo de úlcera gástrica induzida por anti-inflamatório não-esteroidal (indometacina) e modelo de úlcera gástrica induzida por etanol/HCl. RESULTADOS: Os resultados da análise fitoquímica indicaram que a casca e polpa e as sementes de E. mattosii apresentam compostos fenólicos, terpenos e/ou esteroides. No modelo de úlcera gástrica induzido pelo etanol, foi evidenciada redução significativa de áreas danificadas para doses de 50 e 250 mg/kg do extrato das sementes, enquanto no modelo de úlcera induzida por indometacina, todas as partes do fruto apresentaram capacidade de defesa da mucosa gástrica ao reduzir as lesões nas doses de 50, 125 e 250 mg/kg. CONCLUSÃO: Os resultados demonstram que a espécie E. mattosii possui compostos bioativos com atividade gastroprotetora, apresentando possível potencial terapêutico.

Factors associated with consumption of fruits and vegetables by teenagers in Penha, Brazil / Fatores associados ao consumo de frutas e hortaliças em adolescentes no município de Penha, Brasil

Food is essential for the promotion of health and the low intake of fruits and vegetables (FV) is a risk factor for chronic non-communicable diseases. Current descriptive and cross-sectional study evaluated the consumption of FVby teenagers in Penha, Santa Catarina State, Brazil, and its relation to nutritional and socioeconomic status. The study involved 361 adolescents who were assessed through a self-administered questionnaire featuring demographic and socioeconomic variables. Body Mass Index was applied to assess nutritional status coupled to a Food Frequency Questionnaire for Adolescents for the consumption of FV. The sum of the responses was compared to the recommendations of the World Health Organization (>400 g day- 1), ranking them as adequate or inadequate. Results showed the prevalence of males (51%), adherence to physical activity (71%) and eutrophy (65%). Nonetheless, only 32% met the minimum recommendations of FV daily consumption which revealed an inverse association with the consumption of soft drinks. Taking snacks at school makes most teenagers consume less FV. Although no association between the consumption of FV, nutritional and socioeconomic status was found, the consumption of FV is below the recommendations.

A alimentação é primordial para a promoção da saúde, e a baixa ingestão de frutas e hortaliças (FH) é fator de risco para as doenças crônicas não transmissíveis. Esse estudo objetivou avaliar o consumo de FH por adolescentes do município de Penha, Estado de Santa Catarina, Brasil, e sua relação com o perfil nutricional e socioeconômico. Trata-se de um estudo transversal e descritivo com 361 adolescentes avaliados por meio de um questionário auto-aplicável com variáveis demográficas e socioeconômicas. Para avaliar o estado nutricional foi aplicado o Índice de Massa Corporal e para o consumo de FH um Questionário de Frequência Alimentar para Adolescentes, onde se realizou somatória das respostas e comparação às recomendações da Organização Mundial da Saúde (> 400gdia-1), classificando como adequadas e inadequadas. Os resultados mostram prevalência do sexo masculino (51%), adesão à prática de atividade física (71%) e eutrofia (65%). Todavia, somente 32% atenderam as recomendações mínimas do consumo diário de FH, apresentando associação inversa ao consumo de refrigerantes. Nota-se que, ao levar lanches para a escola, a maioria dos adolescentes tende a consumir menos FH. Embora não houvesse associação entre o consumo de FH, estado nutricional e condições socioeconômicas dos adolescentes, foi possível observar que este consumo está aquém das recomendações.